Any one knows what is the best option to separate a mixture of MEG and Crude oil? I have been told no working chemicals can separate them efficiently.

MEG AND HYDROCARBONS ARE IMMISCIBLE.( very slightly misicible)
CRUDE OIL IS AN HYDROCARBON HENCE SHOULD NOT BE SOLUBLE IN MEG.

PROBABALY ADDITION OF WATER TO REDUCE VISCOSITY OF MEG , HEAT TO ABOUT 60 -80 o C TO AVOID EMULSION FORMATION AND CENTRIFUGING SHOULD SEPERATE THE CRUDE AND MEG.

The 2 liquids are immiscible. Gravity settling is simple and effective. If the density of crude oil is too close to that of MEG, add some water (miscible with MEG but not with crude) to increase density

As has been pointed out, the SG of pure MEG is 1.11 at 77°F and 1.085 at 140°F so gravity settling can be used effectively. Normally you are dealing with MEG solution, so SG is closer to 1. We inject MEG at wellheads and recover MEG mixed with production water and hydrocarbons via a 3-phase separator with no big issues. Water-in-oil emulsions are often a pain and apparently, MEG helps in the breaking of these emulsions together with emulsion breakers. So no, you don't need chemicals to separate HC and MEG.

Thanks for the comments made. As clearly pointed out, 3-phase gravitational separation would do the job handsomely at temp around 60-70 degree C. I have been told by a process engineer in a prominent Oil and Gas company that MEG tends to mix with crude, thus needs additional unit of operations to recover MEG fully. Can you guys clarify on that.

hydrocarbons C7 and higher exhibit some solubility but feel that the presence of water and high affinity of MEG for water should resist even C7 and higher hydrocarbons from dissolving in the MEG/WATER/CRUDE OIL MIX

Immiscible is an exaggeration, of course. Gravity separation will get almost all of the MEG out of your crude, but there will always be some left Aker Process Systems (based in Oslo, Norway) have a system to remove the MEG by vacuum distillation, which is about the only way to do it. Water and MEG will be removed together in this system. You can then regenerate the MEg and reuse it. Receiving facilities, such as BP Grangemouth, do not like having methanol or MEG in the crude, as it is hard to remove efficiently and cheaply, so you will probably have to remove all but traces.